Description

4-(Trifluoromethyl)Thiazole-2-Carboxylic Acid is a high-value heterocyclic building block featuring a carboxylic acid group and a trifluoromethyl-substituted thiazole ring. This compound matters as a critical intermediate for synthesizing advanced pharmaceuticals and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability, lipophilicity, and bioavailability. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiazole moiety.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials and polymers where the thiazole ring contributes to charge transport properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A fundamental building block for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	4-(Trifluoromethyl)Thiazole-2-Carboxylic Acid
CAS No.	944900-55-4
Molecular Formula	C5H2F3NO2S
Molecular Weight	197.14 g/mol
Synonyms	2-Thiazolecarboxylic acid, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)-1,3-thiazole-2-carboxylic acid; 4-(Trifluoromethyl)thiazole-2-carboxylic acid; 4-Trifluoromethylthiazole-2-carboxylic acid; 2-Carboxy-4-trifluoromethylthiazole; 4-TFMTA
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Thiazole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.