Description

5-Trifluoromethyl-4H-[1,2,4]Triazole-3-Carboxylic Acid is a high-value trifluoromethylated heterocyclic building block essential for modern synthetic chemistry. Its core value lies in the unique combination of the triazole scaffold and the trifluoromethyl group, which imparts desirable properties such as enhanced metabolic stability and lipophilicity to target molecules. This compound is critically needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group improves bioactivity and environmental persistence.
• Material Science Precursor: Serves as a building block for specialty polymers, ligands, and functional materials requiring specific electronic or steric properties.
• Chemical Biology Probe Development: Employed in medicinal chemistry to create molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up services.

Basic Information

Product Name	5-Trifluoromethyl-4H-[1,2,4]Triazole-3-Carboxylic Acid
CAS No.	944897-41-0
Molecular Formula	C4H2F3N3O2
Molecular Weight	181.07 g/mol
Synonyms	4H-1,2,4-Triazole-3-carboxylic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-1H-1,2,4-triazole-3-carboxylic acid; 5-Trifluoromethyl-1,2,4-triazole-3-carboxylic acid; 3-Carboxy-5-trifluoromethyl-1,2,4-triazole; 5-Trifluoromethyl-4H-1,2,4-triazole-3-carboxylic acid; 944897-41-0; AKOS005258155
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethyl-4H-[1,2,4]Triazole-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and production standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.