Description

Chloro[(R)-(+)-5,5'-Bis(Diphenylphosphino)-4,4'-Bi-1,3-Benzodioxole](p-Cymene)Ruthenium(II) Chloride [RuCl(p-Cymene)((R)-Segphos)]Cl is a high-purity, chiral ruthenium complex widely recognized as a premier catalyst for asymmetric hydrogenation and other enantioselective transformations. Its value lies in enabling the efficient and highly selective synthesis of optically active intermediates critical for advanced pharmaceutical and fine chemical manufacturing. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-performance catalysts to develop novel chiral compounds.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of ketones, imines, and olefins to produce chiral alcohols, amines, and saturated compounds.
• Pharmaceutical Intermediate Synthesis: Key catalyst in the production of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Fine Chemical Manufacturing: Used in the synthesis of complex, high-value chiral molecules for agrochemicals, flavors, and fragrances.
• Academic and Industrial R&D: A valuable tool for method development and exploring new catalytic asymmetric reactions.
• Process Chemistry Optimization: Employed in scaling up enantioselective reactions from laboratory to pilot and production scale.

Basic Information

Product Name	Chloro[(R)-(+)-5,5'-Bis(Diphenylphosphino)-4,4'-Bi-1,3-Benzodioxole](p-Cymene)Ruthenium(II) Chloride [RuCl(p-Cymene)((R)-Segphos)]Cl
CAS No.	944451-28-9
Molecular Formula	C55H48Cl2O4P2Ru
Molecular Weight	989.88 g/mol
Synonyms	(R)-Segphos Ru(p-cymene) chloride complex; Dichloro[(R)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole](p-cymene)ruthenium(II); RuCl(p-cymene)[(R)-Segphos]; Ruthenium, dichloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene][(5,5'-bis[diphenylphosphino]-4,4'-bi-1,3-benzodioxole-κP,κP']-,(R)-; (R)-SegPhos-Ru(II)(p-cymene)Cl2; [RuCl((R)-segphos)(p-cymene)]Cl; Asymmetric Hydrogenation Catalyst Ru-(R)-Segphos
EINECS	Contact for details

Quality Control

Every batch of our chiral ruthenium catalyst is produced and tested under strict quality management protocols to ensure consistent high performance and purity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as assay, enantiomeric purity of the ligand, and residual solvent content. Our quality systems support the needs of cGMP-compliant pharmaceutical manufacturing, and we can accommodate specific customer testing requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain catalytic activity and shelf life.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (Ligand)	≥ 99.0% ee
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.