Description

Chloro{(R)-(+)-2,2'-Bis[Di(3,5-Xylyl)Phosphino]-1,1'-Binaphthyl}(p-Cymene)Ruthenium(II) Chloride [RuCl(p-Cymene)((R)-Xylbinap)]Cl is a high-value, chiral ruthenium complex widely recognized as a premier asymmetric hydrogenation catalyst. Its core value lies in enabling the production of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs) with exceptional selectivity and efficiency. This product is essential for R&D chemists and process engineers in the pharmaceutical, fine chemical, and agrochemical industries seeking to develop and scale up stereoselective synthetic routes.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of prochiral ketones, olefins, and imines to produce chiral alcohols, amines, and other high-value intermediates.
• Pharmaceutical Intermediate Synthesis: Critical in the synthesis of chiral active pharmaceutical ingredients (APIs) for cardiovascular, central nervous system (CNS), and anti-infective drugs.
• Fine Chemical Production: Used in the manufacture of enantiopure flavors, fragrances, and specialty agrochemicals.
• Academic and Industrial R&D: A benchmark catalyst for developing new asymmetric transformations and optimizing existing catalytic processes.
• Process Chemistry & Scale-up: Suitable for transfer from laboratory-scale discovery to pilot plant and commercial manufacturing due to its robustness and high turnover numbers.

Basic Information

Product Name	Chloro{(R)-(+)-2,2'-Bis[Di(3,5-Xylyl)Phosphino]-1,1'-Binaphthyl}(p-Cymene)Ruthenium(II) Chloride [RuCl(p-Cymene)((R)-Xylbinap)]Cl
CAS No.	944451-24-5
Molecular Formula	C72H66Cl2P2Ru
Molecular Weight	1184.09 g/mol
Synonyms	(R)-XylBINAP-Ru(p-cymene)Cl]Cl; [RuCl((R)-Xylbinap)(p-cymene)]Cl; Ruthenium, chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene][(1R)-1,1'-binaphthalene-2,2'-diylbis[bis[3,5-dimethylphenyl]phosphine]]-, chloride (1:1); (R)-XylBINAP-Ru(p-cymene) chloride complex; RuCl(p-cymene)[(R)-XylBINAP]Cl; Asymmetric Hydrogenation Catalyst Ru-XylBINAP; (R)-2,2'-Bis(di-3,5-xylylphosphino)-1,1'-binaphthyl(p-cymene)ruthenium(II) dichloride
EINECS	Contact for details

Quality Control

Every batch of our Chloro{(R)-(+)-2,2'-Bis[Di(3,5-Xylyl)Phosphino]-1,1'-Binaphthyl}(p-Cymene)Ruthenium(II) Chloride is synthesized and handled under strict inert atmosphere conditions to preserve catalytic activity. Our products undergo rigorous quality testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) with detailed specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, cold environment. This compound is easily oxidized and hygroscopic; prolonged exposure to air, moisture, or elevated temperatures will degrade its catalytic performance.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Residual Solvents (GC)	Meet ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.