Description

(2E)-4,4-Difluorobut-2-Enoic Acid CAS NO 944328-71-6 is a high-purity, fluorinated α,β-unsaturated carboxylic acid building block. This compound is valued for its unique chemical reactivity, serving as a versatile synthon for introducing difluoroalkene and carboxylic acid functionalities into target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the difluoroalkene moiety enhances biological activity and metabolic stability.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored surface properties.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry and the development of activity-based protein profiling (ABPP) reagents.
• Organic Synthesis: Acts as a Michael acceptor in conjugate addition reactions and a precursor for various heterocyclic compounds.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and the effects of fluorine substitution.

Basic Information

Product Name	(2E)-4,4-Difluorobut-2-Enoic Acid
CAS No.	944328-71-6
Molecular Formula	C4H4F2O2
Molecular Weight	122.07 g/mol
Synonyms	(E)-4,4-Difluorobut-2-Enoic Acid; trans-4,4-Difluorocrotonic Acid; 4,4-Difluorobut-2-Enoic Acid; 4,4-Difluorocrotonic Acid; (2E)-4,4-Difluoro-2-butenoic Acid; 4,4-Difluoro-2-butenoic Acid; (E)-4,4-Difluoro-2-butenoic Acid; 2-Butenoic acid, 4,4-difluoro-, (2E)-
EINECS	Contact for details

Quality Control

Our (2E)-4,4-Difluorobut-2-Enoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent identity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from incompatible materials such as bases, oxidizing agents, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.