Description

1H-Pyrrolo[2,3-B]Pyridine, 3-Phenyl-1-(Phenylsulfonyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional boronic ester derivative used as a key synthetic intermediate in advanced organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is critical for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, leveraging its boronic ester functionality for structure-activity relationship (SAR) studies.
• Material Science Research: Serves as a precursor for creating organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated pyrrolopyridine core.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to form new carbon-carbon bonds, facilitating the modular construction of complex organic molecules.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic applications.
• Academic & Contract Research: A valuable reagent for synthetic methodology development and exploratory chemistry in academic and contract research organizations (CROs).

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 3-Phenyl-1-(Phenylsulfonyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	943323-25-9
Molecular Formula	C25H25BN2O4S
Molecular Weight	460.35 g/mol
Synonyms	3-Phenyl-1-(phenylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-4-boronic acid, 3-phenyl-1-(phenylsulfonyl)-, pinacol ester; 943323-25-9; 3-Phenyl-1-tosyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; Sulfonyl-protected pyrrolopyridine boronic ester; 1-(Benzenesulfonyl)-3-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine boronic ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent specifications for research and development use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.