Description

4'-Fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid is a high-value biphenyl carboxylic acid derivative distinguished by its fluorine and trifluoromethyl substituents. This compound is a critical pharmaceutical intermediate and advanced building block for medicinal chemistry, enabling the synthesis of novel active ingredients. It is primarily required by R&D laboratories and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing new drug candidates and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anti-inflammatory drug research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its fluorine-containing aromatic scaffold.
• Agrochemical Synthesis: Intermediate in the development of advanced herbicides and fungicides with enhanced bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display materials.
• Organic Synthesis: Versatile reagent for Suzuki-Miyaura and other cross-coupling reactions to create complex biaryl systems.
• Chemical Research: Used in academic and industrial R&D for exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	4'-Fluoro-3'-(Trifluoromethyl)-[1,1'-Biphenyl]-4-Carboxylic Acid
CAS No.	942475-07-2
Molecular Formula	C14H8F4O2
Molecular Weight	284.21 g/mol
Synonyms	[1,1'-Biphenyl]-4-carboxylic acid, 4'-fluoro-3'-(trifluoromethyl)-; 4'-Fluoro-3'-(trifluoromethyl)biphenyl-4-carboxylic acid; 4-(4-Fluoro-3-(trifluoromethyl)phenyl)benzoic acid; 4'-Fluoro-3'-trifluoromethylbiphenyl-4-carboxylic acid; 942475-07-2; 4'-Fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid; 4'-Fluoro-3'-(trifluoromethyl)biphenyl-4-carboxylic acid; 4-(4-Fluoro-3-trifluoromethylphenyl)benzoic acid
EINECS	Contact for details

Quality Control

Our 4'-Fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and organic solvents. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.