Description

2-Bromo-5-(Methylsulphonyl)Aniline is a high-purity, specialized aromatic amine derivative featuring both bromine and methylsulfonyl substituents. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block in organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and receptor antagonist research.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and plant growth regulators, leveraging its halogen and sulfone functional groups.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig aminations.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing high-performance, light-fast azo dyes and complex organic pigments.
• Chemical Research & Development: A valuable building block in medicinal chemistry and process chemistry for structure-activity relationship (SAR) studies and route scouting.

Basic Information

Product Name	2-Bromo-5-(Methylsulphonyl)Aniline
CAS No.	942474-24-0
Molecular Formula	C7H8BrNO2S
Molecular Weight	250.11 g/mol
Synonyms	2-Bromo-5-(methylsulfonyl)benzenamine; 5-Amino-2-bromophenyl methyl sulfone; 2-Bromo-5-methanesulfonylaniline; Benzenamine, 2-bromo-5-(methylsulfonyl)-; 2-Bromo-5-methylsulfonylaniline; 2-Bromo-5-(methylsulfonyl)phenylamine; 2-Br-5-Ms-Aniline
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-(Methylsulphonyl)Aniline is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes comprehensive analysis via HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We support development and commercial projects requiring ICH stability data and can supply material compliant with cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.