Description

2-[(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Oxy]Acetic Acid is a specialized fluorinated organic acid building block of significant interest in advanced chemical synthesis. Its unique structure, featuring a trifluoromethylated tert-butyl ether group directly attached to an acetic acid moiety, makes it a valuable precursor for introducing sterically hindered, lipophilic, and electron-withdrawing motifs. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical sectors. It enables the synthesis of novel active ingredients with potentially enhanced metabolic stability, bioavailability, and target specificity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting protease inhibitors, kinase inhibitors, and other small-molecule therapeutics where the trifluoromethyl group is desirable.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where its fluorinated structure can contribute to improved lipophilicity and environmental persistence profiles.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral and achiral ligands, as well as organocatalysts, utilized in asymmetric synthesis and other catalytic transformations.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers, such as polyesters or polyacrylates, to incorporate fluorine for altered surface properties, chemical resistance, or optical characteristics.
• Fluorine Chemistry Building Block: A versatile starting material for further functionalization in organofluorine chemistry, enabling the construction of complex molecules with tailored physical and chemical properties for various high-value applications.

Basic Information

Product Name	2-[(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Oxy]Acetic Acid
CAS No.	942215-79-4
Molecular Formula	C6H9F3O3
Molecular Weight	186.13 g/mol
Synonyms	Acetic acid, 2-[(1,1,1-trifluoro-2-methyl-2-propanyl)oxy]-; 2-[(1,1,1-Trifluoro-2-methylpropan-2-yl)oxy]acetic acid; 2-((1,1,1-Trifluoro-2-methylpropan-2-yl)oxy)acetic acid; 2-(1,1,1-Trifluoro-2-methyl-2-propoxy)acetic acid; (1,1,1-Trifluoro-2-methyl-2-propoxy)acetic acid; TFMP-O-Acetic Acid; HG-942215-79-4
EINECS	Contact for details

Quality Control

Our production of 2-[(1,1,1-Trifluoro-2-Methylpropan-2-Yl)Oxy]Acetic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assay and identity confirmation via NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its acidic nature and light-sensitive properties, prolonged exposure to elevated temperatures or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.