Description

4-Bromo-1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, multi-functional heterocyclic boronic ester building block. This compound is essential for modern synthetic chemistry, particularly in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing pyrazole cores.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides through palladium-catalyzed cross-coupling.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLED emitters and charge transport layers.
• Chemical Biology & Medicinal Chemistry: Enables the late-stage functionalization and diversification of lead compounds in drug discovery programs.
• Ligand & Catalyst Development: Employed in the preparation of novel bidentate or polydentate ligands for catalytic systems.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	4-Bromo-1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	942070-88-4
Molecular Formula	C10H16BBrN2O2
Molecular Weight	287.97 g/mol
Synonyms	1-Methyl-4-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 4-Bromo-1-methyl-1H-pyrazole-5-boronic acid pinacol ester; 1-Methyl-4-bromo-1H-pyrazole-5-boronic acid pinacol ester; 942070-88-4; 4-Bromo-1-methyl-5-(pinacolboranyl)-1H-pyrazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-bromo-1-methyl-1H-pyrazole; Pyrazole boronic ester, 4-bromo-1-methyl-; 4-Bromo-1-methylpyrazole-5-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity building blocks for GMP intermediates and advanced research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.