Description

T-Butyl 3,5-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate is a high-purity, protected boronic ester derivative of a pyrrolopyridine heterocycle, serving as a critical building block in modern synthetic chemistry. Its value lies in providing a stable, reactive handle for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, particularly for developing novel active ingredients and functional organic compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used to construct novel heterocyclic scaffolds for new herbicides, fungicides, and insecticides.
• Organic Light-Emitting Diodes (OLEDs): Serves as a building block for electron-transport or host materials in display and lighting technologies.
• Polymer Chemistry: Enables the incorporation of functional heterocyclic units into specialty polymers and dendrimers.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Facilitates the modular assembly of linker molecules and ligands for targeted protein degradation.
• Material Science: Used in the development of organic semiconductors, conductive polymers, and metal-organic frameworks (MOFs).
• Academic & Contract Research: A versatile reagent for methodology development and library synthesis in medicinal and combinatorial chemistry.

Basic Information

Product Name	T-Butyl 3,5-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate
CAS No.	942070-54-4
Molecular Formula	C27H40B2N2O5
Molecular Weight	502.24 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; tert-Butyl 3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(tert-butoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine; 1-Boc-3,5-bis(pinacolboron)-7-azaindole; 1-Boc-3,5-bis(Bpin)-7-azaindole; 3,5-BisBpin-1-Boc-7-azaindole; 7-Azaindole-3,5-bis(boronic acid pinacol ester) N-Boc protected
EINECS	Contact for details

Quality Control

Our T-Butyl 3,5-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storing under an inert gas in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.