Description

5-Acetylthiophene-2-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound is valued for its stability as a protected boronic acid derivative, which is crucial for controlled cross-coupling reactions like the Suzuki-Miyaura reaction. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing functionalized thiophene scaffolds.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable organoboron reagent for palladium-catalyzed carbon-carbon bond formation, enabling the construction of biaryl and heterobiaryl structures.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that incorporate acetylthiophene motifs.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors, conductive polymers, and light-emitting materials for electronic devices.
• Chemical Biology & Probe Synthesis: Useful for creating molecular probes and labeled compounds for biochemical and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	5-Acetylthiophene-2-Boronic Acid Pinacol Ester
CAS No.	942070-32-8
Molecular Formula	C13H19BO3S
Molecular Weight	266.16 g/mol
Synonyms	5-Acetyl-2-thienylboronic acid pinacol ester; (5-Acetylthiophen-2-yl)boronic acid pinacol ester; 2-(5-Acetylthiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Acetyl-2-thiopheneboronic acid pinacol ester; Pinacol (5-acetylthiophen-2-yl)boronate; 5-Acetylthiophene-2-boronic acid neopentyl glycol ester (common alternative); 942070-32-8; 5-Acetyl-2-thienyl-Bpin
EINECS	Contact for details

Quality Control

Our 5-Acetylthiophene-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available for every lot and provided upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.