Description

2-(4-Boc-Piperazin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester is a high-value, protected boronic acid ester building block crucial for modern synthetic chemistry, particularly in cross-coupling reactions. Its primary value lies in enabling the efficient and selective construction of complex nitrogen-containing heterocycles, which are core scaffolds in many active pharmaceutical ingredients. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical and agrochemical industries engaged in drug discovery, lead optimization, and the synthesis of novel bioactive molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key electrophilic partner for constructing biaryl and heteroaryl linkages in complex molecules.
• Pharmaceutical Intermediate Synthesis: For the research and development of new drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry & Lead Optimization: Used to rapidly generate analog libraries by introducing the pyrimidine-piperazine moiety into various molecular frameworks.
• Agrochemical Research: In the synthesis of novel herbicides, fungicides, and insecticides containing advanced heterocyclic systems.
• Chemical Biology & Probe Development: For creating tool compounds and molecular probes to study biological pathways.
• Material Science Precursor: Potential use in synthesizing organic electronic materials and metal-organic frameworks (MOFs) with specific ligand properties.

Basic Information

Product Name	2-(4-Boc-Piperazin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	940284-98-0
Molecular Formula	C19H29BN4O4
Molecular Weight	388.27 g/mol
Synonyms	2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyrimidine-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[4-[(tert-butoxy)carbonyl]-1-piperazinyl]pyrimidine; 2-(N-Boc-piperazin-1-yl)pyrimidine-5-boronic acid pinacol ester; tert-Butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl]piperazine-1-carboxylate; 940284-98-0; 2-(4-Boc-piperazinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
EINECS	Contact for details

Quality Control

Our 2-(4-Boc-Piperazin-1-Yl)Pyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including NMR, HPLC, and LC-MS for comprehensive characterization and purity verification. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent decomposition. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.