Description

tert-Butyl 4-(2-Nitro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine-1-Carboxylate is a high-purity (95%) advanced pharmaceutical intermediate featuring a protected piperazine ring and a boronic ester pinacol group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronic ester moiety serves as a key coupling partner for constructing biaryl and heterobiaryl systems central to many drug molecules.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of new therapeutic agents, particularly in oncology, CNS disorders, and anti-infective fields.
• Protected Piperazine Scaffold Introduction: The tert-butyloxycarbonyl (Boc)-protected piperazine allows for selective deprotection and further functionalization, a common strategy in medicinal chemistry.
• Chemical Biology & Proteolysis Targeting Chimera (PROTAC) Development: Acts as a versatile linker or component in the synthesis of bifunctional molecules for targeted protein degradation.
• Agrochemical Research: Employed in the synthesis of novel compounds for crop protection and agrochemical discovery.
• Material Science Precursor: Potential use in creating organic electronic materials or metal-organic frameworks (MOFs) due to its aromatic and coordinating boronate structure.

Basic Information

Item	Details
Product Name	tert-Butyl 4-(2-Nitro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine-1-Carboxylate
CAS No.	940284-94-6
Molecular Formula	C21H32BN3O6
Molecular Weight	433.31 g/mol
Synonyms	1-Boc-4-[2-Nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine; tert-Butyl 4-[2-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate; 4-(2-Nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-[2-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine; 940284-94-6; Boronic acid, B-[4-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]-3-nitrophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Nitro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity (≥95%), and consistency suitable for research and development applications. Comprehensive Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.