Description

9-Fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals, where the introduction of fluorine can dramatically alter biological activity and metabolic stability. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and material science industries seeking to innovate new molecular entities.

Application

• Pharmaceutical Intermediate: Serves as a critical scaffold for the synthesis of central nervous system (CNS) active drugs, receptor modulators, and other therapeutic agents.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides where the benzoazepine core provides unique biological activity.
• Material Science Precursor: Acts as a building block for specialty polymers, liquid crystals, or organic electronic materials due to its rigid, fused-ring structure.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a fluorinated analog in drug discovery programs.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and the exploration of new heterocyclic chemistry.
• Custom Synthesis: A starting material for the tailored synthesis of more complex, fluorinated benzo-fused nitrogen heterocycles for client-specific projects.

Basic Information

Product Name	9-Fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepine
CAS No.	939759-18-9
Molecular Formula	C10H12FN
Molecular Weight	165.21 g/mol
Synonyms	9-Fluoro-2,3,4,5-tetrahydro-1H-1-benzazepine; 9-Fluoro-1,2,3,4-tetrahydro-5H-benzo[b]azepine; 9-Fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepin; 9-Fluoro-1,2,3,4-tetrahydrobenzo[b]azepine; 9-Fluoro-5H-2,3,4,5-tetrahydro-1-benzazepine; 9-Fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepine; 9-Fluoro-2,3,4,5-tetrahydrobenzo[b]azepine
EINECS	Contact for details

Quality Control

Our 9-Fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.