Description

8-Trifluoromethyl-3,4-Dihydro-2H-Benzo[1,4]Oxazine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring a benzoxazine scaffold with a strategically positioned trifluoromethyl group, makes it a critical intermediate for developing novel compounds with enhanced biological activity and physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets, anti-infectives, and oncology applications.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and lipophilicity.
• Material Science: Investigated as a monomer or building block for specialty polymers and advanced materials with unique surface properties or optical characteristics.
• Chemical Biology: Employed as a probe or tag in medicinal chemistry programs to study structure-activity relationships (SAR) and optimize lead compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines for clinical trial materials.

Basic Information

Product Name	8-Trifluoromethyl-3,4-Dihydro-2H-Benzo[1,4]Oxazine
CAS No.	939759-08-7
Molecular Formula	C9H8F3NO
Molecular Weight	203.16 g/mol
Synonyms	2H-1,4-Benzoxazine, 3,4-dihydro-8-(trifluoromethyl)-; 3,4-Dihydro-8-(trifluoromethyl)-2H-1,4-benzoxazine; 8-(Trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine; 8-Trifluoromethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine; 8-CF3-3,4-dihydro-2H-benzo[1,4]oxazine; Benzo[1,4]oxazine, 8-trifluoromethyl-3,4-dihydro-2H-; 939759-08-7
EINECS	Contact for details

Quality Control

Our 8-Trifluoromethyl-3,4-Dihydro-2H-Benzo[1,4]Oxazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with every batch and is available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.