Description

5,7-Difluoro-2,3-Dihydro-1-Benzofuran-3-Amine is a high-purity, functionalized benzofuran derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors seeking to incorporate its unique difluorinated benzofuran scaffold into new molecular entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or building block for novel fluorinated polymers and organic electronic materials.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	5,7-Difluoro-2,3-Dihydro-1-Benzofuran-3-Amine
CAS No.	939757-44-5
Molecular Formula	C8H7F2NO
Molecular Weight	171.15 g/mol
Synonyms	3-Amino-5,7-difluoro-2,3-dihydrobenzofuran; 5,7-Difluoro-2,3-dihydro-3-benzofuranamine; 5,7-Difluoro-3-amino-2,3-dihydrobenzofuran; 2,3-Dihydro-5,7-difluorobenzofuran-3-amine; 939757-44-5; 3-Amino-5,7-difluoro-2,3-dihydro-1-benzofuran
EINECS	Contact for details

Quality Control

Our 5,7-Difluoro-2,3-Dihydro-1-Benzofuran-3-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (Specific enantiomer available)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.