Description

(2E)-2-Cyano-3-(3,5-Difluorophenyl)Acrylamide is a high-purity, specialized organic intermediate featuring a cyanoacrylamide core flanked by a difluorophenyl group. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical agents and agrochemicals, enabling the introduction of specific fluorinated motifs that can enhance biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel small-molecule therapeutics or crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, receptor antagonists, and other targeted small-molecule drugs, leveraging the fluorinated aromatic system.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the difluorophenyl-acrylamide structure contributes to efficacy.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing activity-based probes (ABPs) or covalent inhibitors to study enzyme function.
• Material Science Research: Investigated as a monomer or precursor for functional polymers and advanced organic electronic materials due to its conjugated system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring this specific fluorinated acrylamide derivative.

Basic Information

Product Name	(2E)-2-Cyano-3-(3,5-Difluorophenyl)Acrylamide
CAS No.	937600-51-6
Molecular Formula	C10H6F2N2O
Molecular Weight	208.17 g/mol
Synonyms	2-Propenamide, 2-cyano-3-(3,5-difluorophenyl)-, (2E)-; (E)-2-Cyano-3-(3,5-difluorophenyl)acrylamide; 3,5-Difluorocinnamamide, 2-cyano-; (Z)-2-Cyano-3-(3,5-difluorophenyl)acrylamide (Isomer); 3-(3,5-Difluorophenyl)-2-cyanoacrylamide; NSC 760051; 937600-51-6
EINECS	Contact for details

Quality Control

Our (2E)-2-Cyano-3-(3,5-Difluorophenyl)Acrylamide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) documenting batch-specific results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.