Description

5-Chloro-2-Fluoropyridine-3-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the pyridine core for bioactivity.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, ligands for catalysts, and liquid crystals.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronic ester group provides enhanced stability and reactivity for forming carbon-carbon bonds between aromatic and heteroaromatic systems.
• Library Synthesis for Drug Discovery: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening in medicinal chemistry programs.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	5-Chloro-2-Fluoropyridine-3-Boronic Acid Pinacol Ester
CAS No.	937595-72-7
Molecular Formula	C11H14BClFNO2
Molecular Weight	255.50 g/mol
Synonyms	(5-Chloro-2-fluoropyridin-3-yl)boronic acid pinacol ester; 3-Boronic acid, 5-chloro-2-fluoropyridine-, pinacol ester; 5-Chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Fluoro-5-chloropyridine-3-boronic acid pinacol ester; Pinacol (5-chloro-2-fluoropyridin-3-yl)boronate; 937595-72-7; Boronic acid, B-(5-chloro-2-fluoro-3-pyridinyl)-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoropyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for prolonged stability, especially after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.