Description

5-Chloro-2-Fluoropyridin-3-Ylboronic Acid is a high-value boronic acid derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling the precise construction of complex molecules through palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing pyridine-based drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides with specific modes of action.
• Material Science Research: Serves as a precursor for creating functionalized polymers, ligands for catalysis, and organic electronic materials.
• Chemical Biology: Employed in the synthesis of molecular probes and bioconjugates for studying biological processes.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura couplings to form biaryl and heterobiaryl structures central to many functional molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales.

Basic Information

Product Name	5-Chloro-2-Fluoropyridin-3-Ylboronic Acid
CAS No.	937595-70-5
Molecular Formula	C5H4BClFNO2
Molecular Weight	175.36 g/mol
Synonyms	(5-Chloro-2-fluoropyridin-3-yl)boronic acid; 3-Borono-5-chloro-2-fluoropyridine; 5-Chloro-2-fluoro-3-pyridineboronic acid; 5-Chloro-2-fluoropyridine-3-boronic acid; 937595-70-5; AKOS005258315; BRN 12511386
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoropyridin-3-Ylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports applications in GMP and research-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.