Description

(Benzotriazol-1-Yloxy)Dipiperidinocarbenium Tetrafluoroborate is a highly reactive peptide coupling reagent, commonly known as TDBTU. It matters for its efficiency in facilitating amide bond formation under mild conditions, minimizing racemization in sensitive peptide synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for API development and advanced organic synthesis.

Application

• Primary reagent for peptide coupling in solid-phase and solution-phase synthesis.
• Critical intermediate in the production of pharmaceutical active ingredients (APIs), especially complex peptides.
• Used in bioconjugation techniques for labeling proteins and other biomolecules.
• Facilitates macrocyclization reactions in the synthesis of cyclic peptides and natural product analogs.
• Employed in medicinal chemistry research for the rapid assembly of amide libraries.
• Applicable in the synthesis of specialty polymers and advanced materials requiring precise amide linkages.

Basic Information

Product Name	(Benzotriazol-1-Yloxy)Dipiperidinocarbenium Tetrafluoroborate
CAS No.	136605-16-8
Molecular Formula	C17H24BF4N5O
Molecular Weight	401.21 g/mol
Synonyms	TDBTU; (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium Tetrafluoroborate (common misnomer); 1-[(Benzotriazol-1-yloxy)dipiperidinocarbenium] Tetrafluoroborate; Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium Hexafluorophosphate Analog; Peptide Coupling Reagent TDBTU; BOP-Reagent Analog; Carbenium-based Coupling Agent
EINECS	Contact for details

Quality Control

Our (Benzotriazol-1-Yloxy)Dipiperidinocarbenium Tetrafluoroborate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.