Description

Pyrimidine-2-Boronic Acid Pinacol Ester is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, catalyst development, and the synthesis of functionalized heterocycles.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in creating complex pyrimidine-based scaffolds for oncology, antiviral, and CNS therapies.
• Agrochemical Synthesis: Used in the research and development of new active ingredients for herbicides, fungicides, and insecticides that require specific heterocyclic structures.
• Material Science: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs and other functional polymers.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for methodology development and library synthesis via cross-coupling reactions.
• Ligand Synthesis: Used to prepare sophisticated boronic acid-containing ligands for catalysis and molecular recognition applications.
• Process Chemistry: Employed in scaling up synthetic routes for commercial production where robust and selective coupling steps are required.

Basic Information

Product Name	Pyrimidine-2-Boronic Acid Pinacol Ester
CAS No.	937593-41-4
Molecular Formula	C10H15BN2O2
Molecular Weight	206.06 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; Pyrimidin-2-ylboronic Acid Pinacol Ester; 2-Pyrimidineboronic Acid Pinacol Ester; 2-(Pyrimidin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Pyrimidylboronic Acid Pinacol Ester; B-(2-Pyrimidinyl)boronic Acid Pinacol Ester; CAS 937593-41-4
EINECS	Contact for details

Quality Control

Our Pyrimidine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.