Description

1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-1-Yl)Ethanone is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group, making it a critical building block for modern synthetic chemistry. Its core value lies in enabling efficient, high-yield Suzuki-Miyaura cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who are developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a versatile coupling partner to form carbon-carbon bonds, enabling the construction of biaryl and heterobiaryl structures prevalent in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Serves as a building block for developing new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Research: Employed in the creation of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated indole core.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) agents for target identification and validation.
• Academic & Contract Research: A valuable reagent for methodology development and scale-up synthesis in academic laboratories and contract research organizations (CROs).

Basic Information

Item	Details
Product Name	1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-1-Yl)Ethanone
CAS No.	937591-32-7
Molecular Formula	C16H22BNO3
Molecular Weight	287.17 g/mol
Synonyms	1-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indol-1-yl]ethanone; 1-Acetyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-indolinyl ethyl ketone; 1-Acetyl-5-(pinacolatoboryl)indoline; 5-(Pinacolatoboryl)-1-acetylindoline; N-Acetyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline; 937591-32-7
EINECS	Contact for details

Quality Control

Our 1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-1-Yl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.