Description

2-Acetyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,4-Tetrahydroisoquinoline is a high-value, advanced pharmaceutical intermediate featuring a tetrahydroisoquinoline core functionalized with a pinacol boronate ester group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient Suzuki-Miyaura cross-coupling reactions to construct complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of tetrahydroisoquinoline-based drug candidates targeting central nervous system (CNS) disorders, oncology, and cardiovascular diseases.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety enables efficient palladium-catalyzed coupling with aryl/heteroaryl halides, facilitating rapid library synthesis for drug discovery.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging the structural complexity of the tetrahydroisoquinoline scaffold.
• Material Science Precursor: Serves as an organic precursor for creating functionalized polymers or organic electronic materials with specific optoelectronic properties.
• Academic & Contract Research: Essential reagent in university laboratories and CROs (Contract Research Organizations) for methodological development and synthetic chemistry projects.

Basic Information

Item	Detail
Product Name	2-Acetyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	937591-29-2
Molecular Formula	C₁₇H₂₄BNO₃
Molecular Weight	301.19 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-acetyl-1,2,3,4-tetrahydroisoquinoline; 1-(7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one; 2-Acetyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline; 7-Pinacolatoboryl-2-acetyl-1,2,3,4-tetrahydroisoquinoline; Boronic acid, B-[2-(acetyl-1,2,3,4-tetrahydro-7-isoquinolinyl)]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Acetyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.