Description

Methyl 5,5,5-Trifluoro-4-(4-Methoxyphenylamino)Pentanoate CAS NO 937371-63-6 is a high-purity fluorinated organic building block, specifically a trifluoromethyl-substituted amino acid ester derivative. This compound is valued for its role as a key synthetic intermediate in the development of advanced pharmaceuticals and agrochemicals, where the introduction of fluorine atoms is critical for modulating biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced properties.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs) with trifluoromethyl groups, particularly in CNS and oncology research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where fluorine substitution improves efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a specialty intermediate in the synthesis of fluorinated organic compounds for electronic display and lighting applications.
• Peptidomimetics & Bioactive Molecule Research: The amino ester functionality makes it valuable for constructing fluorinated peptide analogs and other bioactive scaffolds in medicinal chemistry.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed and other metal-mediated coupling reactions to create complex fluorinated architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	Methyl 5,5,5-Trifluoro-4-(4-Methoxyphenylamino)Pentanoate
CAS No.	937371-63-6
Molecular Formula	C13H16F3NO3
Molecular Weight	291.27 g/mol
Synonyms	Methyl 4-[(4-methoxyphenyl)amino]-5,5,5-trifluoropentanoate; 5,5,5-Trifluoro-4-[(4-methoxyphenyl)amino]pentanoic Acid Methyl Ester; 4-(4-Methoxyanilino)-5,5,5-trifluoropentanoic Acid Methyl Ester; Methyl 5,5,5-trifluoro-4-(p-anisidino)pentanoate; Trifluoromethyl Aniline Pentanoate Ester; 937371-63-6 (CAS Name); MFCD30129027
EINECS	Contact for details

Quality Control

Our Methyl 5,5,5-Trifluoro-4-(4-Methoxyphenylamino)Pentanoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and we support custom synthesis to meet specific purity (e.g., >98%, >99%) or impurity profile requirements for advanced research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.