Description

3-Ethoxycarbonyl-1,2-Benzisothiazole-5-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and a versatile building block for organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and functional materials, particularly through Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing complex molecules in drug discovery and development, especially for candidates containing the benzisothiazole pharmacophore.
• Suzuki-Miyaura Cross-Coupling: Serves as a crucial boronic ester reagent for forming carbon-carbon bonds, enabling the construction of biaryl and heterobiaryl structures.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring specific heterocyclic frameworks.
• Material Science: A precursor for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology: Employed in the synthesis of probes and ligands for studying biological targets and pathways.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for clients.

Basic Information

Product Name	3-Ethoxycarbonyl-1,2-Benzisothiazole-5-Boronic Acid Pinacol Ester
CAS No.	936923-42-1
Molecular Formula	C₁₆H₂₀BNO₄S
Molecular Weight	333.21 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-benzisothiazole-3-carboxylic acid ethyl ester; Ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-benzisothiazole-3-carboxylate; 1,2-Benzisothiazole-5-boronic acid, 3-(ethoxycarbonyl)-, pinacol ester; Benzisothiazole boronic ester; Boronate ester intermediate CAS 936923-42-1
EINECS	Contact for details

Quality Control

Our 3-Ethoxycarbonyl-1,2-Benzisothiazole-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee batch-to-batch consistency and traceability for our global customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.