Description

2,4-Dimethoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidine is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in its role as a versatile intermediate for the Suzuki-Miyaura cross-coupling reaction, enabling the efficient construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality reagents for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in creating novel pyrimidine-based compounds for oncology and antiviral therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators that incorporate the pyrimidine moiety.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, via cross-coupling reactions.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic applications.
• Academic & Industrial R&D: A fundamental reagent for method development and exploring new synthetic pathways in organic chemistry laboratories worldwide.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates and fine chemicals under cGMP or research-grade conditions.

Basic Information

Item	Details
Product Name	2,4-Dimethoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidine
CAS No.	936250-17-8
Molecular Formula	C₁₂H₁₉BN₂O₄
Molecular Weight	266.10 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,4-dimethoxypyrimidine; 2,4-Dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2,4-Dimethoxypyrimidine-5-boronic acid pinacol ester; Pyrimidine-5-boronic acid, 2,4-dimethoxy-, 1,3,2-dioxaborolane deriv.; 936250-17-8; (2,4-Dimethoxypyrimidin-5-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2,4-Dimethoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and commercial synthesis. Certificates of Analysis (COA) with detailed HPLC/GC and NMR data are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.