Description

2-(2,3-Dichloro-5-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound is a critical intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research and development. It is primarily used by R&D chemists and process development scientists in the life sciences and advanced materials sectors for constructing novel chemical entities via cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing biaryl scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific chlorinated, methoxy-substituted aromatic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its boronic ester functionality.
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of molecular probes and tool compounds for target validation and drug discovery campaigns.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke fine chemicals for client projects.

Basic Information

Product Name	2-(2,3-Dichloro-5-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	936249-22-8
Molecular Formula	C13H17BCl2O3
Molecular Weight	303.99 g/mol
Synonyms	2,3-Dichloro-5-methoxyphenylboronic acid pinacol ester; (2,3-Dichloro-5-methoxyphenyl)boronic acid pinacol ester; 2,3-Dichloro-5-methoxybenzeneboronic acid pinacol ester; 2-(2,3-Dichloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 936249-22-8; 2,3-Dichloro-5-methoxy phenylboronic acid pinacol ester; Pinacol (2,3-dichloro-5-methoxyphenyl)boronate
EINECS	Contact for details

Quality Control

Our 2-(2,3-Dichloro-5-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the boronic ester group.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.