Description

Urea, n-(4-Methylphenyl)-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]- is a specialized organic compound that serves as a valuable synthetic intermediate, combining a urea core with a pinacol boronate ester functional group. This dual functionality makes it a critical building block for constructing complex molecular architectures, particularly in advanced pharmaceutical and materials science research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for applications in cross-coupling reactions and medicinal chemistry.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety makes this compound a key reagent for forming carbon-carbon bonds, essential in synthesizing complex biaryl structures for drug candidates and organic materials.
• Pharmaceutical Intermediate: Used in the research and development of new active pharmaceutical ingredients (APIs), particularly those requiring a urea pharmacophore linked to an aromatic system.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides that utilize urea-based active ingredients.
• Organic Light-Emitting Diode (OLED) Materials: Acts as a building block for creating electron-transport or host materials in OLED devices due to its conjugated aromatic-urea-boronate structure.
• Polymer Chemistry: Can be incorporated as a monomer or cross-linking agent in the synthesis of specialty polymers with tailored thermal or electronic properties.
• Chemical Biology & Proteomics: Utilized as a probe or linker in bioconjugation strategies and the development of enzyme inhibitors.

Basic Information

Product Name	Urea, n-(4-Methylphenyl)-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-
CAS No.	935660-80-3
Molecular Formula	C20H25BN2O3
Molecular Weight	352.24 g/mol
Synonyms	1-(4-Methylphenyl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; N-(4-Methylphenyl)-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 4-Methylphenyl-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; Urea Derivative CAS 935660-80-3; Boronic ester urea derivative; Pinacol boronate urea; Boro-Urea Intermediate
EINECS	Contact for details

Quality Control

Our production of Urea, n-(4-Methylphenyl)-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is fully characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the boronate ester group.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.