Description

Urea, n-(2-Methylphenyl)-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]- is a specialized organic compound featuring a urea core functionalized with both an o-tolyl group and a pinacol boronate ester. This unique molecular architecture makes it a versatile and valuable intermediate in modern synthetic chemistry, particularly for constructing complex molecules via cross-coupling reactions. It is primarily sought after by pharmaceutical, agrochemical, and advanced materials research sectors for the development of new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in kinase inhibitor and oncology research.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection products, leveraging the boronate ester for efficient carbon-carbon bond formation.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a precursor in the synthesis of electron-transport or host materials for display and lighting technologies.
• Polymer Chemistry: Monomer or functionalization agent for producing specialty polymers with tailored thermal, mechanical, or electronic properties.
• Chemical Biology & Proteomics: Utilized in the development of molecular probes and activity-based protein profiling (ABPP) agents due to its reactive urea and boronate functionalities.
• Academic & Contract Research: Essential reagent for methodological development in organic synthesis and catalysis studies within R&D laboratories.

Basic Information

Item	Detail
Product Name	Urea, n-(2-Methylphenyl)-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-
CAS No.	935660-79-0
Molecular Formula	C20H25BN2O3
Molecular Weight	352.24 g/mol
Synonyms	1-(2-Methylphenyl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; N-(o-Tolyl)-N'-[4-(pinacolatoboryl)phenyl]urea; 4-(3-(o-Tolyl)ureido)phenylboronic acid pinacol ester; Urea, N-(2-methylphenyl)-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; B-[4-[[(2-Methylphenyl)amino]carbonylamino]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of Urea, n-(2-Methylphenyl)-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]- adheres to a strict quality management system to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to verify identity and purity. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.