Description

1,1'-Biphenyl, 4-Chloro-3-(Trifluoromethyl)- is a high-value, multi-functional biphenyl derivative distinguished by its chloro and trifluoromethyl substituents. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Active Ingredient Precursor: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the stability imparted by the biphenyl core.
• Liquid Crystal & OLED Material Synthesis: Serves as a core structure for creating novel organic electronic materials due to its rigid, planar biphenyl framework and electron-withdrawing groups.
• Polymer Science & Specialty Chemicals: Acts as a monomer or additive to impart specific thermal, chemical, or optical properties to high-performance polymers and coatings.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct more complex biaryl systems.
• Organic Synthesis & Catalysis Research: Employed in academic and industrial laboratories as a standard or novel reagent for methodology development and catalyst testing.

Basic Information

Product Name	1,1'-Biphenyl, 4-Chloro-3-(Trifluoromethyl)-
CAS No.	935546-50-2
Molecular Formula	C13H8ClF3
Molecular Weight	256.65 g/mol
Synonyms	4-Chloro-3-(trifluoromethyl)biphenyl; 3'-Trifluoromethyl-4-chlorobiphenyl; 4-Chloro-α,α,α-trifluoro-3-biphenylmethane; 4-Chloro-3-trifluoromethyl-1,1'-biphenyl; 1,1'-Biphenyl, 4-chloro-3-(trifluoromethyl)-; 4-Chloro-3-(trifluoromethyl)-1,1'-biphenyl; 3-(Trifluoromethyl)-4-chlorobiphenyl; Biphenyl, 4-chloro-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1,1'-Biphenyl, 4-Chloro-3-(Trifluoromethyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. The container should be kept tightly sealed to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.