Description

T-Butyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrole-1-Carboxylate is a high-value, protected boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and advanced materials research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing functionalized pyrrole cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific heterocyclic structures.
• Material Science: Serves as a monomer or precursor in the development of organic semiconductors, conductive polymers, and advanced organic frameworks (MOFs/COFs).
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester group acts as a stable handle for palladium-catalyzed coupling with aryl/heteroaryl halides, enabling efficient library synthesis.
• Chemical Biology & Proteomics: Utilized in the synthesis of molecular probes, bioconjugation reagents, and tagged compounds for studying biological systems.
• Academic & Contract Research: A critical reagent for methodology development and complex molecule synthesis in university and CRO laboratory settings.

Basic Information

Product Name	T-Butyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrole-1-Carboxylate
CAS No.	935278-73-2
Molecular Formula	C15H24BNO4
Molecular Weight	293.17 g/mol
Synonyms	1-Boc-3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole; tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-1-carboxylate; 3-Boronic acid, 1H-pyrrole-3-, 1-(1,1-dimethylethyl) ester, pinacol ester; 1H-Pyrrole-1-carboxylic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-1-carboxylic acid tert-butyl ester; Boc-3-Pyrroleboronic Acid Pinacol Ester; 1-N-Boc-3-pyrroleboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of T-Butyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrole-1-Carboxylate is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure the material meets the exacting standards required for research and scale-up. Our quality commitment supports compliance with ISO and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.