Description

Benzyl 3,3-Difluorocyclobutanecarboxylate is a high-purity fluorinated cyclobutane derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the unique reactivity and stability imparted by the difluorocyclobutane core, which is essential for constructing complex molecular architectures. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly those targeting enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates incorporating fluorinated cyclobutane motifs to modulate potency and ADMET properties.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides where the difluorocyclobutane group can improve biological activity and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced materials with tailored thermal and chemical resistance.
• Ligand & Catalyst Development: Employed in organometallic chemistry for constructing sophisticated chiral ligands and catalysts used in asymmetric synthesis.
• Fluorine Chemistry Research: A valuable substrate for exploring new fluorination methodologies and C-F bond functionalization reactions in academic and industrial R&D settings.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale commercial batches.

Basic Information

Product Name	Benzyl 3,3-Difluorocyclobutanecarboxylate
CAS No.	935273-86-2
Molecular Formula	C12H12F2O2
Molecular Weight	226.22 g/mol
Synonyms	3,3-Difluorocyclobutanecarboxylic Acid Benzyl Ester; Benzyl 3,3-Difluorocyclobutan-1-carboxylate; 1-(Benzyloxycarbonyl)-3,3-difluorocyclobutane; 935273-86-2; BDFC; BDFC Ester
EINECS	Contact for details

Quality Control

Our Benzyl 3,3-Difluorocyclobutanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.