Description

2-Difluoromethyl-5-Methoxyindole is a high-value, fluorinated indole derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring a difluoromethyl group, is essential for modulating the physicochemical and metabolic properties of target molecules, making it a key building block for research and development. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, including potential drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the difluoromethyl group can enhance biological activity and environmental stability.
• Material Science: Serves as a building block for advanced organic materials, such as organic light-emitting diodes (OLEDs) and specialty polymers.
• Fluorine Chemistry: An important reagent for introducing fluorine atoms into complex molecular architectures to alter lipophilicity, metabolic stability, and binding affinity.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and exploratory synthesis in heterocyclic and fluoroorganic chemistry.

Basic Information

Product Name	2-Difluoromethyl-5-Methoxyindole
CAS No.	934843-28-4
Molecular Formula	C10H9F2NO
Molecular Weight	197.18 g/mol
Synonyms	5-Methoxy-2-(difluoromethyl)-1H-indole; 1H-Indole, 2-(difluoromethyl)-5-methoxy-; 2-(Difluoromethyl)-5-methoxyindole; 5-Methoxy-2-difluoromethylindole
EINECS	Contact for details

Quality Control

Our 2-Difluoromethyl-5-Methoxyindole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.