Description

1-(2',3'-Difluorophenyl)-2-Nitroethene is a specialized nitroalkene derivative featuring a difluorinated aromatic ring, serving as a versatile and high-value synthetic intermediate. This compound is critical for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for its unique reactivity profile.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of drug candidates, especially those targeting central nervous system (CNS) disorders, due to the bioisosteric properties of the fluorine atoms.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the nitroethene moiety acts as a reactive handle for further functionalization.
• Material Science Research: Employed in the development of organic semiconductors and non-linear optical (NLO) materials, leveraging its electron-deficient structure.
• Chemical Biology Probes: Serves as a precursor for activity-based probes and fluorescent tags used in proteomics and diagnostic assay development.
• Cross-Coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions (e.g., Heck, Suzuki) to create complex biaryl systems.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies in organic synthesis and fluorine chemistry.

Basic Information

Product Name	1-(2',3'-Difluorophenyl)-2-Nitroethene
CAS No.	934625-92-0
Molecular Formula	C8H5F2NO2
Molecular Weight	185.13 g/mol
Synonyms	2,3-Difluoro-β-nitrostyrene; (2,3-Difluorophenyl)-2-nitroethene; 1-(2,3-Difluorophenyl)-2-nitroethylene; β-Nitro-2,3-difluorostyrene; NSC 781106; (E)-1-(2,3-Difluorophenyl)-2-nitroethene; (Z)-1-(2,3-Difluorophenyl)-2-nitroethene; 2-Nitro-1-(2,3-difluorophenyl)ethene
EINECS	Contact for details

Quality Control

Our 1-(2',3'-Difluorophenyl)-2-Nitroethene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be performed under subdued lighting or using amber glass containers where practical.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Isomeric Ratio (E/Z)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.