Description

(2S,3R)-3-Hydroxy-2-Methyl-3-(4-Nitrophenyl)Propanal CAS NO 934246-91-0 is a high-purity chiral building block and advanced pharmaceutical intermediate characterized by its distinct stereochemistry and functional groups. This compound matters for its critical role in the enantioselective synthesis of complex bioactive molecules, where its defined stereocenters provide precise control over the final product's three-dimensional structure and biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the production of novel active ingredients and for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) standards.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high stereochemical fidelity.
• Agrochemical Synthesis: Used in the research and development of novel, stereospecific pesticides and herbicides where biological activity is highly dependent on molecular configuration.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in academic and industrial research focused on developing new asymmetric synthetic methodologies.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances that require specific enantiomeric forms for optimal performance.
• Process Chemistry & Scale-Up: Integral for optimizing and scaling synthetic routes from laboratory to pilot plant and commercial production, ensuring reproducibility and cost-efficiency.

Basic Information

Product Name	(2S,3R)-3-Hydroxy-2-Methyl-3-(4-Nitrophenyl)Propanal
CAS No.	934246-91-0
Molecular Formula	C10H11NO4
Molecular Weight	209.20 g/mol
Synonyms	(2S,3R)-3-Hydroxy-2-methyl-3-(4-nitrophenyl)propanal; (2S,3R)-2-Methyl-3-hydroxy-3-(4-nitrophenyl)propanal; 3-Hydroxy-2-methyl-3-(4-nitrophenyl)propanal (stereospecific); (S,R)-3-Hydroxy-2-methyl-3-(4-nitrophenyl)propanal; 4-Nitro-β-methyl-β-hydroxyhydrocinnamaldehyde (stereospecific); Chiral 3-hydroxy aldehyde nitroaryl derivative; (2S,3R)-HMNPP; A chiral nitroaryl propanal intermediate.
EINECS	Contact for details

Quality Control

Every batch of (2S,3R)-3-Hydroxy-2-Methyl-3-(4-Nitrophenyl)Propanal undergoes rigorous analytical testing to ensure it meets the stringent purity and stereochemical integrity requirements of our global clientele. Our quality management system is designed to support development and commercial projects, with testing typically including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and assays for chemical purity. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). For long-term storage, consider storing under an inert gas such as nitrogen or argon in a sealed container. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.