Description

5-[(2,4-Difluorophenoxy)Methyl]Thiophene-2-Carboxylic Acid is a high-value, multifunctional heterocyclic building block designed for advanced chemical synthesis. This compound is critical for research and development in life sciences, serving as a key intermediate for constructing complex molecules with targeted biological activity. It is primarily sought by pharmaceutical, agrochemical, and advanced material industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the difluorophenoxy and thiophene motifs for enhanced bioactivity and selectivity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a core fragment in fragment-based drug discovery (FBDD).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and development candidates.

Basic Information

Product Name	5-[(2,4-Difluorophenoxy)Methyl]Thiophene-2-Carboxylic Acid
CAS No.	934127-23-8
Molecular Formula	C13H8F2O3S
Molecular Weight	282.26 g/mol
Synonyms	2-Thiophenecarboxylic acid, 5-[(2,4-difluorophenoxy)methyl]-; 5-((2,4-Difluorophenoxy)methyl)thiophene-2-carboxylic acid; 5-(2,4-Difluorophenoxymethyl)thiophene-2-carboxylic acid; 934127-23-8; Thiophene-2-carboxylic acid, 5-[(2,4-difluorophenoxy)methyl]-; 5-[(2,4-Difluorophenoxy)methyl]-2-thiophenecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-[(2,4-Difluorophenoxy)Methyl]Thiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.