Description

trans-4-Trifluoromethylcyclohexaneamide is a high-purity fluorinated organic building block characterized by its trans-configured cyclohexane ring bearing a trifluoromethyl amide group. This compound is valued for its unique combination of lipophilicity, metabolic stability, and stereochemical definition, which are critical for advanced chemical synthesis. It serves as a key intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing fluorinated drug candidates, especially in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Advanced Polymer Science: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Chemical Biology & Proteomics: Employed as a probe or labeling reagent due to the distinctive spectroscopic signature of the fluorine atoms.
• Catalysis & Ligand Development: Utilized in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	trans-4-Trifluoromethylcyclohexaneamide
CAS No.	933781-52-3
Molecular Formula	C8H12F3NO
Molecular Weight	195.18 g/mol
Synonyms	trans-4-(Trifluoromethyl)cyclohexanecarboxamide; 4-(Trifluoromethyl)cyclohexanecarboxamide (trans-); trans-4-(Trifluoromethyl)cyclohexanecarboxylic acid amide; 4-(Trifluoromethyl)cyclohexanecarboxylic acid amide (trans-); (1r,4r)-4-(Trifluoromethyl)cyclohexane-1-carboxamide; (trans)-4-Trifluoromethyl-cyclohexanecarboxamide; 933781-52-3; trans-4-Trifluoromethylcyclohexanecarboxamide
EINECS	Contact for details

Quality Control

Our trans-4-Trifluoromethylcyclohexaneamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry standards for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
trans-Isomer Content (HPLC/GC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.