Description

4-Chloropyrimidine-5-Carboxylic Acid is a versatile and high-purity heterocyclic building block essential for advanced organic synthesis. This compound is critical for researchers and manufacturers developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where precise molecular architecture is paramount. Its reactive chloropyrimidine core and carboxylic acid functionality make it a key intermediate for medicinal chemistry, particularly in the synthesis of kinase inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of kinase inhibitors, antiviral agents, and other small-molecule drug candidates.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization, enabling the creation of complex pyrimidine-based libraries for high-throughput screening.
• Material Science: Potential monomer or additive in the research of specialty polymers and advanced organic materials.
• Bioconjugation & Probe Development: The carboxylic acid group allows for coupling to biomolecules or solid supports, useful in creating diagnostic probes or affinity ligands.

Basic Information

Product Name	4-Chloropyrimidine-5-Carboxylic Acid
CAS No.	933686-33-0
Molecular Formula	C5H3ClN2O2
Molecular Weight	158.54 g/mol
Synonyms	5-Carboxy-4-chloropyrimidine; 4-Chloro-5-pyrimidinecarboxylic acid; 4-Chloropyrimidine-5-carboxylic acid; 933686-33-0; 4-Chloro-5-carboxypyrimidine; 4-Chloro-pyrimidine-5-carboxylic acid; 4-Chloro-5-pyrimidine carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Chloropyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, for comprehensive identity and purity verification. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.