Description

4-Bromo-1-Trifluoromethoxy-2-Trifluoromethyl-Benzene is a high-value, multi-fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both trifluoromethoxy and trifluoromethyl substituents adjacent to a bromine handle, makes it a critical intermediate for constructing complex molecules with tailored electronic and physicochemical properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas targeting CNS disorders, oncology, and inflammatory diseases, where fluorinated motifs enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve lipophilicity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify electron density and intermolecular interactions.
• Cross-Coupling Reactions: The bromine atom acts as an excellent site for palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira) to create more complex biaryl and conjugated systems.
• Fluorinated Ligand Development: Utilized in the preparation of sophisticated ligands for catalysis, where the fluorinated groups can significantly influence metal coordination and catalyst performance.

Basic Information

Product Name	4-Bromo-1-Trifluoromethoxy-2-Trifluoromethyl-Benzene
CAS No.	933674-89-6
Molecular Formula	C9H3BrF6O
Molecular Weight	321.02 g/mol
Synonyms	1-Bromo-4-(trifluoromethoxy)-2-(trifluoromethyl)benzene; 4-Bromo-α,α,α,α',α',α'-hexafluoro-o-cresol methyl ether; 2-Trifluoromethyl-4-bromophenyl trifluoromethyl ether; Benzene, 4-bromo-1-(trifluoromethoxy)-2-(trifluoromethyl)-; 4-Bromo-2-(trifluoromethyl)phenyl trifluoromethyl ether
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1-Trifluoromethoxy-2-Trifluoromethyl-Benzene is produced and analyzed under strict quality management protocols to ensure consistency and reliability for your critical research and development processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our commitment to quality assurance supports compliance in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.