Description

5-Trifluoromethyl-Benzo[1,3]Dioxol-2-One is a high-value fluorinated heterocyclic building block, essential for introducing the trifluoromethyl group into complex molecular architectures. This compound is prized for its role in modulating the physicochemical properties of target molecules, enhancing lipophilicity and metabolic stability. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the trifluoromethyl group contributes to improved biological activity and environmental profile.
• Material Science Precursor: Serves as a building block for specialty polymers and advanced organic electronic materials requiring fluorinated components.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development and exploring novel fluorination chemistry and heterocyclic reactions.
• Ligand and Catalyst Design: Useful in the synthesis of sophisticated ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.

Basic Information

Product Name	5-Trifluoromethyl-Benzo[1,3]Dioxol-2-One
CAS No.	933674-87-4
Molecular Formula	C8H3F3O3
Molecular Weight	204.10 g/mol
Synonyms	5-(Trifluoromethyl)-1,3-benzodioxol-2-one; 5-(Trifluoromethyl)-2H-1,3-benzodioxol-2-one; 5-Trifluoromethyl-2-oxo-2H-1,3-benzodioxole; 5-Trifluoromethyl-1,3-benzodioxol-2-one; 933674-87-4; Benzo[1,3]dioxol-2-one, 5-(trifluoromethyl)-; 5-Trifluoromethyl benzodioxolone
EINECS	Contact for details

Quality Control

Our production of 5-Trifluoromethyl-Benzo[1,3]Dioxol-2-One adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data including HPLC purity, NMR, and MS confirmation. Certificates of Analysis (COA) detailing all specifications are available for every batch and provided with shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.