Description

4-Trifluoromethyl-Benzo[1,3]Dioxol-2-One is a specialized fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of the dioxolone ring and the electron-withdrawing trifluoromethyl group, enabling the construction of complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of novel herbicides and fungicides, where the CF₃ group enhances lipophilicity and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers with tailored surface properties.
• Ligand & Catalyst Development: Employed in the preparation of novel chelating ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable substrate for studying novel fluorination reactions and the introduction of fluorinated motifs into complex molecules.

Basic Information

Product Name	4-Trifluoromethyl-Benzo[1,3]Dioxol-2-One
CAS No.	933674-86-3
Molecular Formula	C₉H₃F₃O₃
Molecular Weight	216.11 g/mol
Synonyms	4-(Trifluoromethyl)-1,3-benzodioxol-2-one; 2H-1,3-Benzodioxol-2-one, 4-(trifluoromethyl)-; Benzo[1,3]dioxol-2-one, 4-trifluoromethyl-; 4-Trifluoromethyl-2H-benzo[d][1,3]dioxol-2-one; 4-Trifluoromethyl-1,3-benzodioxole-2-one; 4-CF₃-Benzo-1,3-dioxol-2-one; 4-Trifluoromethylphthalide carbonate (related structure)
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethyl-Benzo[1,3]Dioxol-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.