Description

1-[4-(1,1,2,3,3,3-Hexafluoro-Propoxy)-Phenyl]-Ethanone is a high-value fluorinated aromatic ketone intermediate, prized for its unique chemical structure that combines a hexafluoropropoxy side chain with an acetophenone core. This compound matters for its role in synthesizing advanced materials and active pharmaceutical ingredients (APIs) where the introduction of fluorine atoms is critical for enhancing stability, lipophilicity, and biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries seeking to develop novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, where the fluorine moiety improves metabolic stability and membrane permeability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance, surface properties, and durability.
• Organic Synthesis & Catalysis Research: A valuable substrate in academic and industrial research for studying novel fluorination reactions and catalytic processes.

Basic Information

Product Name	1-[4-(1,1,2,3,3,3-Hexafluoro-Propoxy)-Phenyl]-Ethanone
CAS No.	933673-41-7
Molecular Formula	C11H8F6O2
Molecular Weight	286.17 g/mol
Synonyms	4'-(1,1,2,3,3,3-Hexafluoropropoxy)acetophenone; 1-[4-(Hexafluoropropoxy)phenyl]ethanone; p-(Hexafluoropropoxy)acetophenone; 4-Acetylphenyl hexafluoropropyl ether; Ethanone, 1-[4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-; Acetophenone, 4'-(hexafluoropropoxy)-
EINECS	Contact for details

Quality Control

Our 1-[4-(1,1,2,3,3,3-Hexafluoro-Propoxy)-Phenyl]-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.