Description

4-Fluoro-3-Iodobenzaldehyde Dimethyl Acetal is a versatile and highly functionalized aromatic building block. This compound is of significant value in advanced organic synthesis, particularly for the construction of complex molecules where precise halogen and protected aldehyde functionality are required. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and as a precursor to various heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated and iodinated aromatic systems.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides that benefit from the unique electronic properties of the fluorine and iodine substituents.
• Material Science Precursor: Serves as a building block for advanced organic materials, such as liquid crystals and organic semiconductors.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Stille couplings to create biaryl structures.
• Protected Aldehyde Source: The acetal group provides a protected form of the aldehyde, allowing for selective manipulation of other functional groups before deprotection.
• Ligand and Catalyst Synthesis: Employed in the preparation of specialized ligands for catalysis and molecular recognition studies.

Basic Information

Item	Detail
Product Name	4-Fluoro-3-Iodobenzaldehyde Dimethyl Acetal
CAS No.	933585-48-9
Molecular Formula	C9H10FIO2
Molecular Weight	296.08 g/mol
Synonyms	1-Fluoro-2-iodo-5-(dimethoxymethyl)benzene; 4-Fluoro-3-iodobenzaldehyde dimethyl acetal; (4-Fluoro-3-iodophenyl)dimethoxymethane; Benzaldehyde, 4-fluoro-3-iodo-, dimethyl acetal; Dimethyl (4-fluoro-3-iodobenzylidene) acetal
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Iodobenzaldehyde Dimethyl Acetal is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.