Description

Chlorodifluoromethyl Phenyl Sulfone is a specialized organosulfur compound featuring a reactive chlorodifluoromethyl group. This chemical serves as a versatile and high-value building block in advanced organic synthesis, enabling the introduction of the difluoromethylthio or difluoromethylene moiety. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients. Its unique structure makes it critical for developing compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethyl group can improve efficacy and environmental profile.
• Material Science Research: Employed in the development of novel polymers and functional materials with specific electronic or surface properties.
• Fluorination Reagent: Acts as a source of the SCF2Cl group in nucleophilic or radical fluorination reactions to construct complex fluorinated molecules.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form carbon-carbon bonds in complex molecular architectures.

Basic Information

Product Name	Chlorodifluoromethyl Phenyl Sulfone
CAS No.	930836-30-9
Molecular Formula	C7H5ClF2O2S
Molecular Weight	226.63 g/mol
Synonyms	Phenyl Chlorodifluoromethyl Sulfone; (Chlorodifluoromethyl)sulfonylbenzene; 1-Chloro-2,2-difluoro-2-phenylethanesulfone; Benzenesulfonyl Chloride, Difluoromethyl-; α-Chloro-α,α-difluorotoluene Sulfone
EINECS	Contact for details

Quality Control

Our Chlorodifluoromethyl Phenyl Sulfone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and process development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.