Description

2-Difluoromethyl-6-Hydroxy-3H-Pyrimidin-4-One is a high-value, fluorinated pyrimidinone derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring a difluoromethyl group, makes it a versatile building block for introducing fluorine atoms into target molecules, a key strategy for modulating their physicochemical and biological properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced metabolic stability, bioavailability, and efficacy.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in antiviral, anticancer, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the difluoromethyl group can improve lipophilicity and environmental stability.
• Fluorine Chemistry Research: Serves as a specialized reagent for studying fluorination reactions and constructing complex fluorinated heterocycles in academic and industrial R&D settings.
• Material Science Precursor: Potential use in the synthesis of fluorinated organic materials, such as ligands for catalysis or components for specialty polymers.

Basic Information

Product Name	2-Difluoromethyl-6-Hydroxy-3H-Pyrimidin-4-One
CAS No.	929903-21-9
Molecular Formula	C5H4F2N2O2
Molecular Weight	162.10 g/mol
Synonyms	6-Hydroxy-2-(difluoromethyl)-3,4-dihydropyrimidin-4-one; 2-(Difluoromethyl)-6-hydroxy-3H-pyrimidin-4-one; 4(3H)-Pyrimidinone, 2-(difluoromethyl)-6-hydroxy-; 929903-21-9; DFMHPO
EINECS	Contact for details

Quality Control

Our production of 2-Difluoromethyl-6-Hydroxy-3H-Pyrimidin-4-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and KF titration for moisture content. Certificates of Analysis (COA) documenting all test results are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.