Description

1-Chloro-3-(Trifluoromethyl)-5-(3,3,3-Trifluoroprop-1-En-2-Yl)Benzene is a high-value, multi-fluorinated aromatic building block essential for advanced chemical synthesis. This compound matters for its unique structure, which combines a chlorinated benzene ring with trifluoromethyl and trifluoropropenyl substituents, offering significant potential for modulating the electronic and steric properties of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved lipophilicity, membrane permeability, and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorinated aromatic units.
• Cross-Coupling Reactions: The chloro substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Buchwald-Hartwig) to construct complex biaryl systems.
• Fluorine Chemistry Research: An important compound for academic and industrial research focused on understanding structure-activity relationships (SAR) in fluorinated aromatic systems.
• Ligand and Catalyst Development: Utilized as a backbone for synthesizing novel fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Chloro-3-(Trifluoromethyl)-5-(3,3,3-Trifluoroprop-1-En-2-Yl)Benzene
CAS No.	928783-56-6
Molecular Formula	C10H5ClF6
Molecular Weight	274.59 g/mol
Synonyms	1-Chloro-3-(trifluoromethyl)-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene; 2-[3-Chloro-5-(trifluoromethyl)phenyl]-3,3,3-trifluoropropene; 3-Chloro-α,α,α,5-tetrakis(trifluoromethyl)styrene; (3-Chloro-5-(trifluoromethyl)phenyl)(trifluoro)ethene; 1-Chloro-3-trifluoromethyl-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene; 928783-56-6; Benzene, 1-chloro-3-(trifluoromethyl)-5-(3,3,3-trifluoroprop-1-en-2-yl)-
EINECS	Contact for details

Quality Control

Our production of 1-Chloro-3-(Trifluoromethyl)-5-(3,3,3-Trifluoroprop-1-En-2-Yl)Benzene adheres to a strict quality management system to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Purity (HPLC/GC)	≥ 99.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.