Description

4-Isoxazoleboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds to introduce the isoxazole moiety into target molecules.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing isoxazole heterocycles.
• Agrochemical Compound Development: Employed in creating novel herbicides, fungicides, and insecticides with specific biological activity.
• Material Science Research: Acts as a precursor for synthesizing organic ligands, polymers, and functional materials with tailored electronic properties.
• Medicinal Chemistry & Drug Discovery: Facilitates the rapid exploration of chemical space in lead optimization and structure-activity relationship (SAR) studies.
• Chemical Biology Probe Development: Useful for creating labeled compounds or inhibitors for studying biological pathways.

Basic Information

Product Name	4-Isoxazoleboronic Acid Pinacol Ester
CAS No.	928664-98-6
Molecular Formula	C9H14BNO3
Molecular Weight	195.03 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole; 4-Isoxazoleboronic Acid Pinacol Ester; 4-(Pinacolboryl)isoxazole; 4-Isoxazolylboronic Acid Pinacol Ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxazole; Pinacol 4-Isoxazoleboronate
EINECS	Contact for details

Quality Control

Our 4-Isoxazoleboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring reliable and reproducible performance in sensitive synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.