Description

4-(Pyrrolidine-1-Sulfonyl)Phenylboronic Acid, Pinacol Ester is a sophisticated organoboron building block designed for advanced synthetic chemistry. This compound is valued for its dual functionality, combining a boronic ester group for Suzuki-Miyaura cross-coupling reactions with a pyrrolidine sulfonamide moiety that can serve as a key pharmacophore or handle for further derivatization. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the efficient construction of complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting sulfonamide-based enzyme inhibitors.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester partner for palladium-catalyzed carbon-carbon bond formation to create biaryl and heterobiaryl structures.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and for the parallel synthesis of novel compounds for structure-activity relationship (SAR) studies.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides that incorporate sulfonamide functional groups.
• Material Science Precursor: Can be utilized in the synthesis of organic electronic materials and metal-organic frameworks (MOFs) with specific ligand properties.
• Chemical Biology Probes: Acts as a starting material for creating activity-based probes to study biological pathways involving sulfonamide interactions.

Basic Information

Product Name	4-(Pyrrolidine-1-Sulfonyl)Phenylboronic Acid, Pinacol Ester
CAS No.	928657-21-0
Molecular Formula	C16H24BNO4S
Molecular Weight	337.24 g/mol
Synonyms	4-(1-Pyrrolidinesulfonyl)phenylboronic acid pinacol ester; 4-(Pyrrolidine-1-sulfonyl)benzeneboronic acid pinacol ester; 2-[4-(Pyrrolidine-1-sulfonyl)phenyl]-5,5-dimethyl-1,3,2-dioxaborinane; 4-(N-Pyrrolidinosulfonyl)phenylboronic acid pinacol ester; B-[4-(1-Pyrrolidinesulfonyl)phenyl]-5,5-dimethyl-1,3,2-dioxaborinane; 928657-21-0; 4-(Pyrrolidine-1-sulfonyl)phenylboronic acid pinanediol ester (common alternative).
EINECS	Contact for details

Quality Control

Our 4-(Pyrrolidine-1-Sulfonyl)Phenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and scale-up activities. We adhere to cGMP principles where applicable to ensure supply chain integrity and batch-to-batch consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent hydrolysis of the boronic ester moiety.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.