Description

2'-tert-Butoxycarbonylamino-Biphenyl-3-Carboxylic Acid is a high-purity, protected amino acid derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise molecular architecture, particularly in the development of novel active pharmaceutical ingredients (APIs) and complex organic materials. It is primarily utilized by pharmaceutical R&D departments, fine chemical manufacturers, and academic research institutions focused on peptide mimetics, heterocyclic chemistry, and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Peptidomimetic Research: Used to incorporate biphenyl scaffolds into peptide backbones, enhancing metabolic stability and receptor binding affinity.
• Protecting Group Chemistry: The tert-butoxycarbonyl (Boc) group provides orthogonal protection for amines in multi-step synthetic sequences.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis.
• Material Science Precursor: Can be utilized in the synthesis of specialty polymers and organic electronic materials.
• Academic & Discovery Chemistry: A valuable reagent for constructing molecular libraries in high-throughput screening and structure-activity relationship (SAR) studies.

Basic Information

Product Name	2'-tert-Butoxycarbonylamino-Biphenyl-3-Carboxylic Acid
CAS No.	927801-42-1
Molecular Formula	C18H19NO4
Molecular Weight	313.35 g/mol
Synonyms	2'-[(tert-Butoxycarbonyl)amino]-[1,1'-biphenyl]-3-carboxylic acid; 2'-(Boc-amino)biphenyl-3-carboxylic acid; 3-Carboxy-2'-Boc-aminobiphenyl; Biphenyl-3-carboxylic acid, 2'-[(1,1-dimethylethoxy)carbonyl]amino]-; 2'-Boc-Amino-[1,1'-biphenyl]-3-carboxylic Acid; N-Boc-2'-Aminobiphenyl-3-carboxylic Acid; [1,1'-Biphenyl]-3-carboxylic acid, 2'-[[(1,1-dimethylethoxy)carbonyl]amino]-
EINECS	Contact for details

Quality Control

Our 2'-tert-Butoxycarbonylamino-Biphenyl-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure compliance with stringent industry standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.